Presenilin 1 Antibody - #AF0245

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产品: Presenilin 1 抗体
货号: AF0245
描述: Rabbit polyclonal antibody to Presenilin 1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse
预测: Rat, Horse, Rabbit, Chicken, Xenopus
蛋白号: P49768
RRID: AB_2833420

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
Presenilin 1 Antibody detects endogenous levels of total Presenilin 1.
RRID:
AB_2833420
引用格式: Affinity Biosciences Cat# AF0245, RRID:AB_2833420.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AD3; Ad3h; FAD; Homo Sapiens Clone CC44 Senilin 1; Presenilin-1 CTF12; Protein S182; PS 1; PS-1; PS1-CTF12; PSEN1; PSN1_HUMAN; PSNL1; S182;

抗原和靶标

免疫原:

A synthesized peptide derived from human Presenilin 1, corresponding to a region within the internal amino acids.

基因/基因ID:
PSEN1(5663)
描述:
PSEN1 probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function.

研究领域

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Notch signaling pathway.   (View pathway)

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

文献引用

1). Inhibition of autophagosome-lysosome fusion contributes to TDCIPP-induced Aβ1-42 production in N2a-APPswe cells. Heliyon, 2024 (PubMed: 38628727) [IF=4.0]

Application: WB    Species: Human    Sample: N2a-APPswe cells

Fig. 1. TDCIPP promotes the production of Aβ1-42. (A) Human Aβ1-40 (Amyloid Beta 1–40) ELISA Kit was used to detect the expression level of Aβ1-40. (B) Human Aβ1-42 (Amyloid Beta 1–42) ELISA Kit was used to detect the expression level of Aβ1-42. (C) Ratio of Aβ1-42 to Aβ1-40 was calculated based on levels of Aβ1-42 and Aβ1-40. (D–E) Western blot analysis and quantification of PS1 expression levels. (F–G) Western blot analysis and quantification of BACE1 expression levels. Data are shown as mean ± SEM. *, p < 0.05, **, p < 0.01.

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