产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12809, RRID:AB_2845770.
展开/折叠
ADH beta subunit; ADH1B; ADH1B_HUMAN; ADH2; Alcohol dehydrogenase 1B; alcohol dehydrogenase 2 (class I), beta polypeptide; Alcohol dehydrogenase 2; Alcohol dehydrogenase subunit beta; Aldehyde reductase; DKFZp686C06125; OTTHUMP00000220192;
抗原和靶标
- P00325 ADH1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
翻译修饰 - P00325 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| Y35 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| Y111 | Phosphorylation | Uniprot | |
| Y150 | Phosphorylation | Uniprot | |
| T151 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| T179 | Phosphorylation | Uniprot | |
| Y181 | Phosphorylation | Uniprot | |
| K213 | Acetylation | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| K331 | Acetylation | Uniprot | |
| K339 | Acetylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| K355 | Acetylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| K367 | Acetylation | Uniprot |
研究背景
Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal.
Cytoplasm.
Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
Belongs to the zinc-containing alcohol dehydrogenase family.
研究领域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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