产品: ALDH5A1 抗体
货号: DF12820
描述: Rabbit polyclonal antibody to ALDH5A1
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 51 kDa; 57kD(Calculated).
蛋白号: P51649
RRID: AB_2845781

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(92%), Zebrafish(80%), Bovine(83%), Horse(92%), Sheep(83%), Rabbit(100%), Dog(83%), Chicken(100%), Xenopus(83%)
克隆:
Polyclonal
特异性:
ALDH5A1 Antibody detects endogenous levels of total ALDH5A1.
RRID:
AB_2845781
引用格式: Affinity Biosciences Cat# DF12820, RRID:AB_2845781.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Aldedehyde dehydrogenase 5 family; Aldehyde dehydrogenase 5 family member A1; Aldehyde dehydrogenase 5A1; Aldehyde dehydrogenase family 5 member A1; ALDH5A 1; Aldh5a1; mitochondrial; Mitochondrial succinate semialdehyde dehydrogenase; NAD(+) dependent succinic semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase; SSADH; SSDH; SSDH_HUMAN; Succinate semialdehyde dehydrogenase; Succinate-semialdehyde dehydrogenase;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P51649 SSDH_HUMAN:

Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.

序列:
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Rabbit
100
Chicken
100
Pig
92
Horse
92
Bovine
83
Sheep
83
Dog
83
Xenopus
83
Zebrafish
80
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P51649 作为底物

Site PTM Type Enzyme
T3 Phosphorylation
S35 Phosphorylation
S55 Phosphorylation
T61 Phosphorylation
S63 Phosphorylation
S83 Phosphorylation
K126 Acetylation
Y128 Phosphorylation
K135 Acetylation
K148 Ubiquitination
Y175 Phosphorylation
T181 Phosphorylation P24941 (CDK2)
K214 Acetylation
K265 Ubiquitination
K279 Ubiquitination
T287 Phosphorylation
K301 Ubiquitination
K358 Acetylation
K365 Acetylation
T378 Phosphorylation
T379 Phosphorylation
K387 Ubiquitination
S498 Phosphorylation
S499 Phosphorylation
Y524 Phosphorylation

研究背景

功能:

Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).

细胞定位:

Mitochondrion.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.

亚基结构:

Homotetramer.

蛋白家族:

Belongs to the aldehyde dehydrogenase family.

研究领域

· Metabolism > Amino acid metabolism > Alanine, aspartate and glutamate metabolism.

· Metabolism > Carbohydrate metabolism > Butanoate metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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