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| 产品: | AMD1 抗体 |
| 货号: | DF12822 |
| 描述: | Rabbit polyclonal antibody to AMD1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 38 kDa; 38kD(Calculated). |
| 蛋白号: | P17707 |
| RRID: | AB_2845783 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12822, RRID:AB_2845783.
展开/折叠
Adenosylmethionine decarboxylase 1; AdoMetDC; AMD1; DCAM_HUMAN; EC 4.1.1.50; FLJ26964; S adenosylmethionine decarboxylase 1; S adenosylmethionine decarboxylase proenzyme; S-adenosylmethionine decarboxylase beta chain; SAMDC;
抗原和靶标
- P17707 DCAM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P17707 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y63 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| Y112 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K276 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot |
研究背景
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
Heterotetramer of two alpha and two beta chains.
Belongs to the eukaryotic AdoMetDC family.
研究领域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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