| 产品: | AP3D1 抗体 |
| 货号: | DF12825 |
| 描述: | Rabbit polyclonal antibody to AP3D1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 110 kDa; 130kD(Calculated). |
| 蛋白号: | O14617 |
| RRID: | AB_2845786 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12825, RRID:AB_2845786.
展开/折叠
Adapter-related protein complex 3 subunit delta-1; adaptor-related protein complex 3, delta 1 subunit; ADTD; AP 3 complex delta subunit; AP-3 complex subunit delta; AP-3 complex subunit delta-1; ap3d1; AP3D1_HUMAN; Delta 1 subunit of adaptor-related protein complex 3; Delta Adaptin; Delta-adaptin; hBLVR; Subunit of putative vesicle coat adaptor complex AP 3;
抗原和靶标
Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.
- O14617 AP3D1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O14617 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| K7 | Ubiquitination | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| Y365 | Phosphorylation | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K386 | Acetylation | Uniprot | |
| K584 | Ubiquitination | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| K610 | Ubiquitination | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| S632 | Phosphorylation | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| S636 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| K673 | Ubiquitination | Uniprot | |
| Y682 | Phosphorylation | Uniprot | |
| S685 | Phosphorylation | Uniprot | |
| S686 | Phosphorylation | Uniprot | |
| S688 | Phosphorylation | Uniprot | |
| T696 | Phosphorylation | Uniprot | |
| S721 | Phosphorylation | Uniprot | |
| Y724 | Phosphorylation | Uniprot | |
| K736 | Acetylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| S759 | Phosphorylation | Uniprot | |
| T762 | Phosphorylation | Uniprot | |
| S764 | Phosphorylation | Uniprot | |
| T778 | Phosphorylation | Uniprot | |
| S788 | Phosphorylation | Uniprot | |
| Y799 | Phosphorylation | Uniprot | |
| K808 | Ubiquitination | Uniprot | |
| K820 | Ubiquitination | Uniprot | |
| T824 | Phosphorylation | Uniprot | |
| T826 | Phosphorylation | Uniprot | |
| S827 | Phosphorylation | Uniprot | |
| S829 | Phosphorylation | Uniprot | |
| S869 | Phosphorylation | Uniprot | |
| S1070 | Phosphorylation | Uniprot | |
| S1071 | Phosphorylation | Uniprot | |
| C1103 | S-Nitrosylation | Uniprot | |
| K1132 | Ubiquitination | Uniprot |
研究背景
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
Cytoplasm. Golgi apparatus membrane>Peripheral membrane protein>Cytoplasmic side.
Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.
AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). Interacts with SLC30A2.
Belongs to the adaptor complexes large subunit family.
研究领域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
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