ASIC2 Antibody - #DF12840
| 产品: | ASIC2 抗体 |
| 货号: | DF12840 |
| 描述: | Rabbit polyclonal antibody to ASIC2 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Rabbit, Dog, Chicken |
| 分子量: | 70 kDa; 58kD(Calculated). |
| 蛋白号: | Q16515 |
| RRID: | AB_2845801 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12840, RRID:AB_2845801.
展开/折叠
ACCN; ACCN1; ACCN1_HUMAN; Acid sensing ion channel 2; Acid-sensing ion channel 2; Amiloride sensitive brain sodium channel; Amiloride sensitive cation channel 1 neuronal (degenerin); Amiloride sensitive cation channel 1 neuronal; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; ASIC2; ASIC2a; BNaC1; BNC1; Brain sodium channel 1; Degenerin; hBNaC1; Mammalian degenerin homolog; MDEG; Neuronal amiloride sensitive cation channel 1;
抗原和靶标
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
- Q16515 ASIC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q16515 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T39 | Phosphorylation | Uniprot | |
| Y357 | Phosphorylation | Uniprot |
研究背景
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Cell membrane>Multi-pass membrane protein.
Note: Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity (By similarity). Interacts with PRKCABP and ASIC3. Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1. Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-2 and mambalgin-3 (By similarity). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin-1 and mambalgin-2 (By similarity).
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.
研究领域
· Organismal Systems > Sensory system > Taste transduction.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
限制条款
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