AXUD1 Antibody - #DF12847

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产品: AXUD1 抗体
货号: DF12847
描述: Rabbit polyclonal antibody to AXUD1
应用: WB
反应: Human, Mouse, Rat, Monkey
预测: Pig, Bovine, Sheep, Rabbit, Dog
分子量: 64 kDa; 64kD(Calculated).
蛋白号: Q96S65
RRID: AB_2845808

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat,Monkey
预测:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
AXUD1 Antibody detects endogenous levels of total AXUD1.
RRID:
AB_2845808
引用格式: Affinity Biosciences Cat# DF12847, RRID:AB_2845808.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

4931429D10Rik; Axin 1 Up-regulated; Axin-1 up-regulated gene 1 protein; CSRN1_HUMAN; CSRNP-1; CSRNP1; Cysteine/serine-rich nuclear protein 1; DKFZp566F164; FAM130B; Protein URAX1; TAIP 3; TAIP-3; TGF beta induced apoptosis protein 3; TGF-beta-induced apoptosis protein 3; URAX1;

抗原和靶标

免疫原:
Uniprot:

Q96S65(CSRN1_HUMAN) >>Visit HPA database.

基因/基因ID:
CSRNP1(64651)
表达:
Q96S65 CSRN1_HUMAN:

Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.

序列:
MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWDSEEEGPWDQMPLPDRDFCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMALRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGVPQAEAGLPPVVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASSSASGTSEAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFGGEEEEEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYSGCSFTSGVLDENANLDASCFLNGGLEGSREGSLPGTSVPPSMDAGRSSSVDLSLSSCDSFELLQALPDYSLGPHYTSQKVSDSLDNIEAPHFPLPGLSPPGDASSCFLESLMGFSEPAAEALDPFIDSQFEDTVPASLMEPVPV

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
67
Chicken
50
Horse
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q96S65 作为底物

Site PTM Type Enzyme
S25 Phosphorylation
S30 Phosphorylation
S32 Phosphorylation
S38 Phosphorylation
T68 Phosphorylation
S71 Phosphorylation
K74 Ubiquitination
R106 Methylation
T110 Phosphorylation

研究背景

功能:

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.

蛋白家族:

Belongs to the AXUD1 family.

文献引用

1). Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway. American journal of translational research, 2023 (PubMed: 37692966) [IF=2.2]

Application: IHC    Species: Human    Sample: cirrhotic tissues and HCC tissues

Figure 1 Expression of the Wnt-1/β-catenin signaling pathway and EMT-associated proteins in cirrhotic tissues and HCC tissues as assessed by immunohistochemistry. A. Orange signal indicates the presence of Wnt-1, β-catenin, and Axin-1. Wnt-1 and Axin-1 were mainly present in the cytoplasm. β-Catenin was mainly expressed on the cell membrane in cirrhotic tissues and in the cytoplasm and nucleus in HCC tissues (magnification, 400×), P

Application: WB    Species: Human    Sample: cirrhotic tissues and HCC tissues

Figure 1 Expression of the Wnt-1/β-catenin signaling pathway and EMT-associated proteins in cirrhotic tissues and HCC tissues as assessed by immunohistochemistry. A. Orange signal indicates the presence of Wnt-1, β-catenin, and Axin-1. Wnt-1 and Axin-1 were mainly present in the cytoplasm. β-Catenin was mainly expressed on the cell membrane in cirrhotic tissues and in the cytoplasm and nucleus in HCC tissues (magnification, 400×), P

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