| 产品: | BCAT1/ECA39 抗体 |
| 货号: | DF12850 |
| 描述: | Rabbit polyclonal antibody to BCAT1/ECA39 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 43 kDa; 43kD(Calculated). |
| 蛋白号: | P54687 |
| RRID: | AB_2845811 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12850, RRID:AB_2845811.
展开/折叠
BCAT; BCAT(c); Bcat1; BCAT1_HUMAN; BCT1; Branched chain amino acid aminotransferase, cytosolic; branched chain amino-acid transaminase 1, cytosolic; branched chain aminotransferase 1; branched chain aminotransferase 1, cytosolic; Branched-chain-amino-acid aminotransferase; cytosolic; DKFZp686E12175; EC 2.6.1.42; ECA39; MECA39; placental protein 18; PNAS 121; PP18; Protein ECA39;
抗原和靶标
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
- P54687 BCAT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P54687 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K2 | Ubiquitination | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| R119 | Methylation | Uniprot | |
| K134 | Acetylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| T370 | Phosphorylation | Uniprot |
研究背景
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Cytoplasm.
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
Homodimer.
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
研究领域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine biosynthesis.
· Metabolism > Metabolism of cofactors and vitamins > Pantothenate and CoA biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > 2-Oxocarboxylic acid metabolism.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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