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| 产品: | Cathepsin L 抗体 |
| 货号: | DF12880 |
| 描述: | Rabbit polyclonal antibody to Cathepsin L |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 分子量: | 30 kDa; 38kD(Calculated). |
| 蛋白号: | P07711 |
| RRID: | AB_2845841 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12880, RRID:AB_2845841.
展开/折叠
Cathepsin L; cathepsin L, 1 b; Cathepsin L1; Cathepsin L1 light chain; CathepsinL; CATL; CATL1_HUMAN; cb15; CTSL; CTSL1; ctsl1b; FLJ31037; hgg1; Major excreted protein; MEP; MGC123162; wu:fb30g09;
抗原和靶标
- P07711 CATL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
翻译修饰 - P07711 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K104 | Sumoylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| N221 | N-Glycosylation | Uniprot | |
| T223 | Phosphorylation | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| Y295 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| C322 | S-Nitrosylation | Uniprot |
研究背景
Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity).
Lysosome. Apical cell membrane>Peripheral membrane protein>Extracellular side.
Note: Localizes to the apical membrane of thyroid epithelial cells.
Dimer of a heavy and a light chain linked by disulfide bonds.
Belongs to the peptidase C1 family.
研究领域
· Cellular Processes > Transport and catabolism > Autophagy - animal. (View pathway)
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Immune diseases > Rheumatoid arthritis.
· Organismal Systems > Immune system > Antigen processing and presentation. (View pathway)
文献引用
Application: WB Species: Human Sample: PTC cells
限制条款
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