| 产品: | CCT4 抗体 |
| 货号: | DF12888 |
| 描述: | Rabbit polyclonal antibody to CCT4 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Rabbit, Dog, Xenopus |
| 分子量: | 58 kDa, 50 kDa; 58kD(Calculated). |
| 蛋白号: | P50991 |
| RRID: | AB_2845849 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12888, RRID:AB_2845849.
展开/折叠
CCT delta; CCT4; CCTD; chaperonin containing t-complex polypeptide 1, delta subunit; chaperonin containing TCP1, subunit 4 (delta); SRB; Stimulator of TAR RNA binding; T complex protein 1 subunit delta; TCP-1-delta;
抗原和靶标
- P50991 TCPD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPENVAPRSGATAGAAGGRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50991 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R8 | Methylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| R19 | Methylation | Uniprot | |
| K21 | Methylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| R27 | Methylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| R49 | Methylation | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K65 | Acetylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| K139 | Acetylation | Uniprot | |
| K139 | Methylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K143 | Ubiquitination | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| R160 | Methylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| T201 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| R206 | Methylation | Uniprot | |
| K209 | Sumoylation | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K232 | Ubiquitination | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| Y269 | Phosphorylation | Uniprot | |
| R274 | Methylation | Uniprot | |
| K288 | Acetylation | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| C295 | S-Nitrosylation | Uniprot | |
| K302 | Acetylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| K319 | Acetylation | Uniprot | |
| K319 | Ubiquitination | Uniprot | |
| K321 | Acetylation | Uniprot | |
| K326 | Acetylation | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K375 | Ubiquitination | Uniprot | |
| C379 | S-Nitrosylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| T385 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| K395 | Acetylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| C410 | S-Nitrosylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| Y449 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| T464 | Phosphorylation | Uniprot | |
| K489 | Acetylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| T538 | Phosphorylation | Uniprot |
研究背景
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Cytoplasm. Melanosome. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Cilium basal body.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with DNAAF4 (By similarity).
Belongs to the TCP-1 chaperonin family.
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