| 产品: | CNKSR3 抗体 |
| 货号: | DF12901 |
| 描述: | Rabbit polyclonal antibody to CNKSR3 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 62 kDa; 62kD(Calculated). |
| 蛋白号: | Q6P9H4 |
| RRID: | AB_2845862 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12901, RRID:AB_2845862.
展开/折叠
CNK homolog protein 3; CNK3; CNKSR family member 3; Connector enhancer of kinase suppressor of ras 3; Connector enhancer of KSR 3; MAGI1; Maguin like protein; Membrane associated guanylate kinase interacting protein like 1; Membrane associated guanylate kinase, WW and PDZ domain containing 1; RP11 486M3 1; RP11 486M3.1;
抗原和靶标
- Q6P9H4 CNKR3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSPPYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEPSLLVSWFTRLKLLTH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6P9H4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K34 | Ubiquitination | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| T300 | Phosphorylation | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| Y365 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| T398 | Phosphorylation | Uniprot | |
| Y426 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| R483 | Methylation | Uniprot | |
| R495 | Methylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot |
研究背景
Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
Cytoplasm. Apical cell membrane>Peripheral membrane protein.
Interacts with epithelial sodium channel ENaC. Interacts directly with SCNN1A (ENaC subunit alpha) and SCNN1B (ENaC subunit beta) C-terminal tails. Interacts with ENaC regulatory proteins NEDD4L, RAF1 and SGK1.
The PDZ domain is required for interaction with ENaC and SGK1, but not for interaction with NEDDL4 and RAF1.
Belongs to the CNKSR family.
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