| 产品: | CYFIP2 抗体 |
| 货号: | DF12927 |
| 描述: | Rabbit polyclonal antibody to CYFIP2 |
| 应用: | WB |
| 反应: | Human, Mouse, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 130 kDa; 148kD(Calculated). |
| 蛋白号: | Q96F07 |
| RRID: | AB_2845888 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12927, RRID:AB_2845888.
展开/折叠
CYFP2; cytoplasmic FMR1 interacting protein 2; KIAA1168; p53 inducible protein; p53-inducible protein 121; PIR121;
抗原和靶标
Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
- Q96F07 CYFP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96F07 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K97 | Ubiquitination | Uniprot | |
| C98 | S-Nitrosylation | Uniprot | |
| Y108 | Phosphorylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K182 | Acetylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K189 | Acetylation | Uniprot | |
| K197 | Acetylation | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| Y254 | Phosphorylation | Uniprot | |
| T256 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| T419 | Phosphorylation | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| K425 | Ubiquitination | Uniprot | |
| S508 | Phosphorylation | Uniprot | |
| K539 | Ubiquitination | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| S592 | Phosphorylation | Uniprot | |
| K597 | Ubiquitination | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| T603 | Phosphorylation | Uniprot | |
| K749 | Ubiquitination | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| K775 | Ubiquitination | Uniprot | |
| K802 | Ubiquitination | Uniprot | |
| K838 | Ubiquitination | Uniprot | |
| K903 | Ubiquitination | Uniprot | |
| Y911 | Phosphorylation | Uniprot | |
| K916 | Ubiquitination | Uniprot | |
| K939 | Ubiquitination | Uniprot | |
| K982 | Ubiquitination | Uniprot | |
| Y991 | Phosphorylation | Uniprot | |
| K1062 | Acetylation | Uniprot | |
| K1062 | Ubiquitination | Uniprot | |
| K1072 | Ubiquitination | Uniprot | |
| K1077 | Ubiquitination | Uniprot | |
| Y1078 | Phosphorylation | Uniprot | |
| T1092 | Phosphorylation | Uniprot | |
| K1107 | Ubiquitination | Uniprot | |
| K1216 | Ubiquitination | Uniprot | |
| K1221 | Ubiquitination | Uniprot | |
| K1234 | Ubiquitination | Uniprot | |
| K1248 | Ubiquitination | Uniprot | |
| K1251 | Ubiquitination | Uniprot | |
| C1265 | S-Nitrosylation | Uniprot | |
| C1278 | S-Nitrosylation | Uniprot |
研究背景
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Cytoplasm. Nucleus. Cytoplasm>Perinuclear region. Cell junction>Synapse>Synaptosome.
Note: Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118).
Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Interacts with FMR1, FXR1 and FXR2 (By similarity). Interacts with FMR1 isoform 6; the interaction occurs in a RNA-dependent manner. Interacts with RAC1 (activated form) which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex (By similarity). Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (By similarity).
Belongs to the CYFIP family.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Genetic Information Processing > Translation > RNA transport.
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