| 产品: | DDX6 抗体 |
| 货号: | DF12937 |
| 描述: | Rabbit polyclonal antibody to DDX6 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 54 kDa; 54kD(Calculated). |
| 蛋白号: | P26196 |
| RRID: | AB_2845898 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12937, RRID:AB_2845898.
展开/折叠
ATP dependent RNA helicase DDX6; ATP dependent RNA helicase p54; DDX6; DEAD (Asp Glu Ala Asp) box polypeptide 6; DEAD box 6; DEAD box protein 6; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase 54kD); FLJ36338; HLR2; Oncogene RCK; P54; Probable ATP-dependent RNA helicase DDX6; RCK;
抗原和靶标
- P26196 DDX6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P26196 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S15 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| T36 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| K67 | Acetylation | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K73 | Acetylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| K74 | Acetylation | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K104 | Acetylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| Y312 | Phosphorylation | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| C324 | S-Nitrosylation | Uniprot | |
| T327 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| R375 | Methylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| Y440 | Phosphorylation | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| K482 | Ubiquitination | Uniprot |
研究背景
In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Sumoylated.
Cytoplasm>P-body. Cytoplasm. Nucleus.
Note: Upon cellular stress, relocalizes to stress granules (PubMed:26184334).
Abundantly expressed in most tissues.
Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with RC3H1 (By similarity). Interacts with ATXN2L. Interacts with MCRIP1. Interacts with MCRIP2. Interacts with NUFIP2. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner.
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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