| 产品: | DNASE2B 抗体 |
| 货号: | DF12952 |
| 描述: | Rabbit polyclonal antibody to DNASE2B |
| 应用: | WB |
| 反应: | Human, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog |
| 分子量: | 42 kDa; 42kD(Calculated). |
| 蛋白号: | Q8WZ79 |
| RRID: | AB_2845913 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12952, RRID:AB_2845913.
展开/折叠
Deoxyribonuclease 2 beta; Deoxyribonuclease 2 beta precursor; Deoxyribonuclease II beta; DLAD; DNase 2 like acid DNase; DNASE 2B; DNase II beta; DNase II like acid DNase; DNASE2; DNase2 like acid DNase; DNASE2B; DnaseIIb; EC 3.1.22.1; Endonuclease DLAD; Lysosomal DNase II; UOX;
抗原和靶标
Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.
- Q8WZ79 DNS2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKQKMMARLLRTSFALLFLGLFGVLGAATISCRNEEGKAVDWFTFYKLPKRQNKESGETGLEYLYLDSTTRSWRKSEQLMNDTKSVLGRTLQQLYEAYASKSNNTAYLIYNDGVPKPVNYSRKYGHTKGLLLWNRVQGFWLIHSIPQFPPIPEEGYDYPPTGRRNGQSGICITFKYNQYEAIDSQLLVCNPNVYSCSIPATFHQELIHMPQLCTRASSSEIPGRLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8WZ79 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T173 | Phosphorylation | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot |
研究背景
Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.
Lysosome.
Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.
Belongs to the DNase II family.
研究领域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
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