| 产品: | DNM2 抗体 |
| 货号: | DF12953 |
| 描述: | Rabbit polyclonal antibody to DNM2 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 100 kDa; 98kD(Calculated). |
| 蛋白号: | P50570 |
| RRID: | AB_2845914 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12953, RRID:AB_2845914.
展开/折叠
CMT2M; CMTDI1; CMTDIB; DI CMTB; Dnm2; DYN II; DYN2; DYN2_HUMAN; Dynamin II; Dynamin-2; Dynamin2; DynaminII; DYNII;
抗原和靶标
- P50570 DYN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P50570 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| C27 | S-Nitrosylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| C86 | S-Nitrosylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| Y125 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| T200 | Phosphorylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| R217 | Methylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| Y231 | Phosphorylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| T280 | Phosphorylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| T353 | Phosphorylation | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| T400 | Phosphorylation | Uniprot | |
| T404 | Phosphorylation | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| Y449 | Phosphorylation | Uniprot | |
| Y463 | Phosphorylation | Uniprot | |
| T527 | Phosphorylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| Y563 | Phosphorylation | Uniprot | |
| K577 | Ubiquitination | Uniprot | |
| S581 | Phosphorylation | Uniprot | |
| T591 | Phosphorylation | Uniprot | |
| Y597 | Phosphorylation | Uniprot | |
| K598 | Acetylation | Uniprot | |
| K598 | Ubiquitination | Uniprot | |
| C607 | S-Nitrosylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| S644 | Phosphorylation | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| Y663 | Phosphorylation | Uniprot | |
| K669 | Ubiquitination | Uniprot | |
| Y726 | Phosphorylation | Uniprot | |
| T755 | Phosphorylation | Uniprot | |
| S759 | Phosphorylation | Uniprot | |
| S761 | Phosphorylation | Uniprot | |
| S762 | Phosphorylation | Uniprot | |
| S764 | Phosphorylation | P24941 (CDK2) , P06493 (CDK1) | Uniprot |
| T766 | Phosphorylation | P06493 (CDK1) | Uniprot |
| R785 | Methylation | Uniprot | |
| S848 | Phosphorylation | Uniprot | |
| R850 | Methylation | Uniprot | |
| R857 | Methylation | Uniprot | |
| R862 | Methylation | Uniprot |
研究背景
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity).
Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).
Cytoplasm. Cytoplasm>Cytoskeleton. Cell junction. Membrane>Clathrin-coated pit. Cell junction>Synapse>Postsynaptic density. Cell junction>Synapse. Midbody. Cell projection>Phagocytic cup. Cytoplasmic vesicle>Phagosome membrane>Peripheral membrane protein.
Note: Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity). Microtubule-associated. Also found in the postsynaptic density of neuronal cells. Co-localizes with PIK3C3 and RAB5A to the nascent phagosome (By similarity).
Ubiquitously expressed.
Interacts with MYOF (By similarity). Interacts with CTTN and ACTN1 (By similarity). Interacts with SHANK1, SHANK2, SH3BP4 and NOSTRIN. Interacts with SNX9. Interacts with SNX33 (via SH3 domain). Interacts with MYO1E (via SH3 domain). Interacts with PSTPIP1. Interacts with CTNND2. May interact with PIK3C3 (By similarity). May be a component of a complex composed of RAB5A (in GDP-bound form), DYN2 and PIK3C3 (By similarity). Interacts with BIN1.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
限制条款
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