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| 产品: | DTX4 抗体 |
| 货号: | DF12963 |
| 描述: | Rabbit polyclonal antibody to DTX4 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 67 kDa; 67kD(Calculated). |
| 蛋白号: | Q9Y2E6 |
| RRID: | AB_2845924 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12963, RRID:AB_2845924.
展开/折叠
Deltex4; Dtx4; DTX4_HUMAN; E3 ubiquitin-protein ligase DTX4; Protein deltex-4; RING finger protein 155; RNF155;
抗原和靶标
- Q9Y2E6 DTX4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y2E6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T243 | Phosphorylation | Uniprot | |
| T245 | Phosphorylation | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| T315 | Phosphorylation | Uniprot | |
| S376 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | Uniprot | |
| Y453 | Phosphorylation | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| S506 | Phosphorylation | Uniprot |
研究背景
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Cytoplasm.
Interacts with NLRP4.
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Belongs to the Deltex family.
研究领域
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
文献引用
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