| 产品: | DYNC1LI2 抗体 |
| 货号: | DF12965 |
| 描述: | Rabbit polyclonal antibody to DYNC1LI2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 50 kDa; 54kD(Calculated). |
| 蛋白号: | O43237 |
| RRID: | AB_2845926 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12965, RRID:AB_2845926.
展开/折叠
Cytoplasmic dynein 1 light intermediate chain 2; cytosolic; DC1L2_HUMAN; DNCLI2; Dync1li2; Dynein cytoplasmic 1 light intermediate chain 2; Dynein light intermediate chain 2; dynein light intermediate chain 2 cytosolic; dynein, cytoplasmic, light intermediate polypeptide 2; LIC-2; LIC2; LIC53/55; OTTHUMP00000174820;
抗原和靶标
- O43237 DC1L2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSPRTQGRGGPASVPSSSPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVTNSSTENEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43237 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K55 | Methylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| Y284 | Phosphorylation | Uniprot | |
| T291 | Phosphorylation | Uniprot | |
| Y292 | Phosphorylation | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| Y336 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| S391 | Phosphorylation | Uniprot | |
| R393 | Methylation | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| R397 | Methylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| S405 | Phosphorylation | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| T410 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| K440 | Ubiquitination | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| S487 | Phosphorylation | Uniprot |
研究背景
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
Cytoplasm>Cytoskeleton.
Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).
Belongs to the dynein light intermediate chain family.
研究领域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
限制条款
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