| 产品: | ERLIN1 抗体 |
| 货号: | DF12983 |
| 描述: | Rabbit polyclonal antibody to ERLIN1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Rabbit, Dog |
| 分子量: | 39 kDa; 39kD(Calculated). |
| 蛋白号: | O75477 |
| RRID: | AB_2845944 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12983, RRID:AB_2845944.
展开/折叠
Band 7 23-211 Keo4 (Interim) similar to C.elegans protein; C10orf69; chromosome 10 open reading frame 69; Endoplasmic reticulum lipid raft-associated protein 1; ER lipid raft associated 1; Erlin 1; Erlin-1; ERLIN1; ERLN1_HUMAN; KE04; KEO4; OTTHUMP00000059425; Protein KE04; SPFH domain containing protein 1; SPFH domain family, member 1; SPFH domain-containing protein 1; SPFH1; SPG62; Stomatin-prohibitin-flotillin-HflC/K domain containing protein 1; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1;
抗原和靶标
Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.
- O75477 ERLN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLPSKEALEPSGENVIQNKESTG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75477 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N108 | N-Glycosylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K269 | Acetylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | Uniprot |
研究背景
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
Endoplasmic reticulum membrane>Single-pass type II membrane protein.
Note: Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.
Forms a heteromeric complex with ERLIN2. In complex with ERLIN2, interacts with RNF170. Interacts with AMFR and SYVN1.
Belongs to the band 7/mec-2 family.
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