| 产品: | FTCD 抗体 |
| 货号: | DF13022 |
| 描述: | Rabbit polyclonal antibody to FTCD |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 53 kDa; 59kD(Calculated). |
| 蛋白号: | O95954 |
| RRID: | AB_2845983 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13022, RRID:AB_2845983.
展开/折叠
Formimidoyltetrahydrofolate cyclodeaminase; Formimidoyltransferase cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase cyclodeaminase; Formiminotransferase-cyclodeaminase; FTCD; FTCD_HUMAN; Glutamate formiminotransferase; Glutamate formyltransferase; LCHC 1; LCHC1; 58K Golgi protein;
抗原和靶标
- O95954 FTCD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95954 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y124 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| Y324 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| R381 | Methylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| R399 | Methylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| R424 | Methylation | Uniprot | |
| R436 | Methylation | Uniprot | |
| R445 | Methylation | Uniprot | |
| S449 | Phosphorylation | Uniprot |
研究背景
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
Binds and promotes bundling of vimentin filaments originating from the Golgi.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Golgi apparatus.
Note: More abundantly located around the mother centriole.
Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure (By similarity).
In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
In the N-terminal section; belongs to the formiminotransferase family.
研究领域
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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