| 产品: | HOP2 抗体 |
| 货号: | DF13066 |
| 描述: | Rabbit polyclonal antibody to HOP2 |
| 应用: | WB |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 25 kDa; 25kD(Calculated). |
| 蛋白号: | Q9P2W1 |
| RRID: | AB_2846027 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13066, RRID:AB_2846027.
展开/折叠
DBD interacting; GT198; Homologous pairing protein 2 homolog; Homologous-pairing protein 2 homolog; HOP2; HOP2_HUMAN; Nuclear receptor coactivator GT198; Proteasome 26S ATPase subunit 3 interacting protein; Proteasome 26S ATPase subunit 3-interacting protein; PSMC3 interacting protein; PSMC3-interacting protein; Psmc3ip; Tat binding protein 1-interacting protein; Tat-binding protein 1-interacting protein; TBP-1-interacting protein; TBP1 interacting protein; TBPIP;
抗原和靶标
- Q9P2W1 HOP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSKGRAEAAAGAAGILLRYLQEQNRPYSSQDVFGNLQREHGLGKAVVVKTLEQLAQQGKIKEKMYGKQKIYFADQDQFDMVSDADLQVLDGKIVALTAKVQSLQQSCRYMEAELKELSSALTTPEMQKEIQELKKECAGYRERLKNIKAATNHVTPEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPDP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9P2W1 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| Y109 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| T122 | Phosphorylation | Uniprot | |
| T155 | Phosphorylation | Uniprot | |
| K159 | Acetylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| T181 | Phosphorylation | Uniprot |
研究背景
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors.
PTM: Phosphorylated by PKA, PKC and MAPK.
Nucleus.
Highly expressed in testis and colon.
Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA (By similarity). Forms a stable heterodimer with MND1. Interacts with PSMC3/TBP1.
Belongs to the HOP2 family.
限制条款
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