产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13129, RRID:AB_2846089.
展开/折叠
CD118; CD118 antigen; FLJ98106; FLJ99923; Leukemia inhibitory factor receptor alpha; Leukemia inhibitory factor receptor; LIF R; LIF receptor; LIF-R; Lifr; LIFR_HUMAN; SJS2; STWS; SWS;
抗原和靶标
- P42702 LIFR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P42702 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N131 | N-Glycosylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| N303 | N-Glycosylation | Uniprot | |
| Y369 | Phosphorylation | Uniprot | |
| Y379 | Phosphorylation | Uniprot | |
| N407 | N-Glycosylation | Uniprot | |
| N426 | N-Glycosylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| Y492 | Phosphorylation | Uniprot | |
| K526 | Ubiquitination | Uniprot | |
| K610 | Acetylation | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| Y759 | Phosphorylation | Uniprot | |
| Y762 | Phosphorylation | Uniprot | |
| K804 | Ubiquitination | Uniprot | |
| Y807 | Phosphorylation | Uniprot | |
| S833 | Phosphorylation | Uniprot | |
| K866 | Ubiquitination | Uniprot | |
| K880 | Acetylation | Uniprot | |
| K880 | Ubiquitination | Uniprot | |
| K886 | Acetylation | Uniprot | |
| K886 | Ubiquitination | Uniprot | |
| S887 | Phosphorylation | Uniprot | |
| K896 | Acetylation | Uniprot | |
| T904 | Phosphorylation | Uniprot | |
| S927 | Phosphorylation | Uniprot | |
| Y974 | Phosphorylation | Uniprot | |
| S1041 | Phosphorylation | Uniprot | |
| S1044 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
| S1047 | Phosphorylation | Uniprot | |
| S1059 | Phosphorylation | Uniprot | |
| S1077 | Phosphorylation | Uniprot |
研究背景
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 2 subfamily.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
限制条款
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