| 产品: | LSM4 抗体 |
| 货号: | DF13133 |
| 描述: | Rabbit polyclonal antibody to LSM4 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 15 kDa; 15kD(Calculated). |
| 蛋白号: | Q9Y4Z0 |
| RRID: | AB_2846093 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13133, RRID:AB_2846093.
展开/折叠
Glycine rich protein; GRP; LSM 4; LSM4 homolog; LSM4 homolog U6 small nuclear RNA associated (S. cerevisiae); LSM4 homolog U6 small nuclear RNA associated; U6 small nuclear RNA associated; U6 snRNA associated Sm like protein 4; U6 snRNA associated Sm like protein; U6 snRNA associated Sm like protein LSm 4; U6 snRNA associated Sm like protein LSm4; YER 112W; YER112W;
抗原和靶标
- Q9Y4Z0 LSM4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9Y4Z0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K52 | Ubiquitination | Uniprot | |
| C59 | S-Nitrosylation | Uniprot | |
| R62 | Methylation | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| R88 | Methylation | Uniprot | |
| R90 | Methylation | Uniprot | |
| R102 | Methylation | Uniprot | |
| R109 | Methylation | Uniprot | |
| R115 | Methylation | Uniprot | |
| R117 | Methylation | Uniprot | |
| R125 | Methylation | Uniprot | |
| K138 | Acetylation | Uniprot |
研究背景
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Nucleus.
Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
Belongs to the snRNP Sm proteins family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
· Genetic Information Processing > Transcription > Spliceosome.
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