| 产品: | MTHFD1 抗体 |
| 货号: | DF13159 |
| 描述: | Rabbit polyclonal antibody to MTHFD1 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 101 kDa; 102kD(Calculated). |
| 蛋白号: | P11586 |
| RRID: | AB_2846119 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13159, RRID:AB_2846119.
展开/折叠
5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase; C 1 tetrahydrofolate synthase cytoplasmic; C1 tetrahydrofolate synthase cytoplasmic; C1 THF synthase; C1-THF synthase; C1TC; C1TC_HUMAN; Cytoplasmic C 1 tetrahydrofolate synthase; Formyltetrahydrofolate synthetase; Methenyltetrahydrofolate cyclohydrolase; Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase; Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase; Methylenetetrahydrofolate dehydrogenase; MTHFC; MTHFD; MTHFD1; NADP dependent cyclohydrolase formyltetrahydrofolate synthetase; OTTHUMP00000180657;
抗原和靶标
- P11586 C1TC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P11586 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| T35 | Phosphorylation | Uniprot | |
| R37 | Methylation | Uniprot | |
| Y52 | Phosphorylation | Uniprot | |
| K56 | Acetylation | Uniprot | |
| K58 | Ubiquitination | Uniprot | |
| K66 | Ubiquitination | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| C195 | S-Nitrosylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K223 | Sumoylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| Y258 | Phosphorylation | Uniprot | |
| K262 | Acetylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| T279 | Phosphorylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| R324 | Methylation | Uniprot | |
| C326 | S-Nitrosylation | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| Y402 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| T471 | Phosphorylation | Uniprot | |
| K473 | Acetylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| R488 | Methylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| R495 | Methylation | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| T505 | Phosphorylation | Uniprot | |
| T511 | Phosphorylation | Uniprot | |
| R539 | Methylation | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| T545 | Phosphorylation | Uniprot | |
| K553 | Acetylation | Uniprot | |
| K553 | Ubiquitination | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| S601 | Phosphorylation | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| T612 | Phosphorylation | Uniprot | |
| K684 | Ubiquitination | Uniprot | |
| K721 | Acetylation | Uniprot | |
| K721 | Ubiquitination | Uniprot | |
| K733 | Ubiquitination | Uniprot | |
| K739 | Acetylation | Uniprot | |
| K739 | Ubiquitination | Uniprot | |
| T761 | Phosphorylation | Uniprot | |
| T763 | Phosphorylation | Uniprot | |
| S765 | Phosphorylation | Uniprot | |
| S771 | Phosphorylation | Uniprot | |
| K784 | Ubiquitination | Uniprot | |
| K793 | Acetylation | Uniprot | |
| K793 | Ubiquitination | Uniprot | |
| K819 | Acetylation | Uniprot | |
| K819 | Ubiquitination | Uniprot | |
| K825 | Ubiquitination | Uniprot | |
| K832 | Ubiquitination | Uniprot | |
| Y834 | Phosphorylation | Uniprot | |
| K848 | Ubiquitination | Uniprot | |
| K854 | Ubiquitination | Uniprot | |
| K866 | Ubiquitination | Uniprot | |
| S870 | Phosphorylation | Uniprot | |
| S872 | Phosphorylation | Uniprot | |
| T882 | Phosphorylation | Uniprot |
研究背景
Cytoplasm.
Ubiquitous.
Homodimer.
This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity.
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
研究领域
· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.
· Metabolism > Global and overview maps > Metabolic pathways.
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