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| 产品: | MTUS1 抗体 |
| 货号: | DF13161 |
| 描述: | Rabbit polyclonal antibody to MTUS1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 114 kDa; 141kD(Calculated). |
| 蛋白号: | Q9ULD2 |
| RRID: | AB_2846121 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13161, RRID:AB_2846121.
展开/折叠
AGTR2-interacting protein; Angiotensin II type 2 receptor interacting protein; AT2 receptor interacting protein; AT2 receptor-binding protein; AT2R binding protein; ATBP; ATIP; ATIP1; DKFZp586D1519; DKFZp686F20243; Erythroid differentiation related; FLJ14295; GK 1; GK1; KIAA1288; Microtubule associated tumor suppressor 1; Mitochondrial tumor suppressor 1; Mitochondrial tumor suppressor gene 1; MP 44; MP44; MTSG 1; MTSG1; MTUS 1; Transcription factor MTSG1;
抗原和靶标
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.
- Q9ULD2 MTUS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFISKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGKSQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGKVTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEKCKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSASSPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSVSALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLRQIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSGKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTGSTPSIASTHSELSTYSNNSGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
翻译修饰 - Q9ULD2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S6 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| T171 | Phosphorylation | Uniprot | |
| K180 | Methylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| T412 | Phosphorylation | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| K462 | Ubiquitination | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| T488 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| S541 | Phosphorylation | Uniprot | |
| T556 | Phosphorylation | Uniprot | |
| T584 | Phosphorylation | Uniprot | |
| T591 | Phosphorylation | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| Y655 | Phosphorylation | Uniprot | |
| S663 | Phosphorylation | Uniprot | |
| S694 | Phosphorylation | Uniprot | |
| T704 | Phosphorylation | Uniprot | |
| T706 | Phosphorylation | Uniprot | |
| S707 | Phosphorylation | Uniprot | |
| S712 | Phosphorylation | Uniprot | |
| S716 | Phosphorylation | Uniprot | |
| S740 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| S760 | Phosphorylation | Uniprot | |
| S761 | Phosphorylation | Uniprot | |
| S762 | Phosphorylation | Uniprot | |
| T766 | Phosphorylation | Uniprot | |
| S767 | Phosphorylation | Uniprot | |
| K786 | Methylation | Uniprot | |
| K790 | Methylation | Uniprot | |
| S791 | Phosphorylation | Uniprot | |
| S799 | Phosphorylation | Uniprot | |
| T800 | Phosphorylation | Uniprot | |
| Y825 | Phosphorylation | Uniprot | |
| T858 | Phosphorylation | Uniprot | |
| S878 | Phosphorylation | Uniprot | |
| S916 | Phosphorylation | Uniprot | |
| K955 | Ubiquitination | Uniprot | |
| S958 | Phosphorylation | Uniprot | |
| K1081 | Acetylation | Uniprot | |
| K1082 | Ubiquitination | Uniprot | |
| K1091 | Acetylation | Uniprot | |
| K1091 | Ubiquitination | Uniprot | |
| S1199 | Phosphorylation | Uniprot | |
| S1203 | Phosphorylation | Uniprot | |
| T1204 | Phosphorylation | Uniprot | |
| S1212 | Phosphorylation | Uniprot | |
| S1224 | Phosphorylation | Uniprot | |
| S1241 | Phosphorylation | Uniprot | |
| S1245 | Phosphorylation | Uniprot | |
| T1247 | Phosphorylation | Uniprot | |
| S1255 | Phosphorylation | Uniprot | |
| S1259 | Phosphorylation | Uniprot | |
| S1264 | Phosphorylation | Uniprot | |
| S1266 | Phosphorylation | Uniprot | |
| S1268 | Phosphorylation | Uniprot |
研究背景
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Mitochondrion. Golgi apparatus. Cell membrane. Nucleus.
Note: In neurons, translocates into the nucleus after treatment with angiotensin-II.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle.
Note: Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.
Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). Isoform 1 associates with microtubules.
Belongs to the MTUS1 family.
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