产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13183, RRID:AB_2846143.
展开/折叠
Immunoglobulin superfamily DCC subclass member 2; NEO1; NEO1_HUMAN; Neogenin; Ngn (gene name);
抗原和靶标
- Q92859 NEO1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92859 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T51 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| Y164 | Phosphorylation | Uniprot | |
| N210 | N-Glycosylation | Uniprot | |
| Y219 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| N470 | N-Glycosylation | Uniprot | |
| N489 | N-Glycosylation | Uniprot | |
| Y602 | Phosphorylation | Uniprot | |
| T603 | Phosphorylation | Uniprot | |
| N639 | N-Glycosylation | Uniprot | |
| T955 | Phosphorylation | Uniprot | |
| S956 | Phosphorylation | Uniprot | |
| S1056 | Phosphorylation | Uniprot | |
| S1057 | Phosphorylation | Uniprot | |
| S1066 | Phosphorylation | Uniprot | |
| S1068 | Phosphorylation | Uniprot | |
| S1080 | Phosphorylation | Uniprot | |
| Y1082 | Phosphorylation | Uniprot | |
| K1173 | Ubiquitination | Uniprot | |
| S1178 | Phosphorylation | Uniprot | |
| T1188 | Phosphorylation | Uniprot | |
| S1194 | Phosphorylation | Uniprot | |
| T1198 | Phosphorylation | Uniprot | |
| S1203 | Phosphorylation | Uniprot | |
| S1214 | Phosphorylation | Uniprot | |
| S1220 | Phosphorylation | Uniprot | |
| Y1279 | Phosphorylation | Uniprot | |
| T1289 | Phosphorylation | Uniprot | |
| S1292 | Phosphorylation | Uniprot | |
| S1294 | Phosphorylation | Uniprot | |
| S1299 | Phosphorylation | Uniprot | |
| T1300 | Phosphorylation | Uniprot | |
| S1302 | Phosphorylation | Uniprot | |
| T1382 | Phosphorylation | Uniprot | |
| S1386 | Phosphorylation | Uniprot | |
| S1401 | Phosphorylation | Uniprot | |
| T1404 | Phosphorylation | Uniprot | |
| S1432 | Phosphorylation | Uniprot | |
| S1434 | Phosphorylation | Uniprot | |
| S1435 | Phosphorylation | Uniprot | |
| Y1436 | Phosphorylation | Uniprot |
研究背景
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Cell membrane>Single-pass type I membrane protein.
Widely expressed and also in cancer cell lines.
Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7.
The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
Belongs to the immunoglobulin superfamily. DCC family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
限制条款
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