NNMT Antibody - #DF13190

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产品: NNMT 抗体
货号: DF13190
描述: Rabbit polyclonal antibody to NNMT
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Dog
分子量: 30 kDa; 30kD(Calculated).
蛋白号: P40261
RRID: AB_2846150

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(83%), Dog(92%)
克隆:
Polyclonal
特异性:
NNMT Antibody detects endogenous levels of total NNMT.
RRID:
AB_2846150
引用格式: Affinity Biosciences Cat# DF13190, RRID:AB_2846150.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EC 2.1.1.1; Nicotinamide N methyltransferase; Nicotinamide N-methyltransferase; NNMT; NNMT_HUMAN;

抗原和靶标

免疫原:
Uniprot:

P40261(NNMT_HUMAN) >>Visit HPA database.

基因/基因ID:
NNMT(4837)
表达:
P40261 NNMT_HUMAN:

Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.

序列:
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Dog
92
Pig
83
Xenopus
45
Horse
0
Bovine
0
Sheep
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P40261 作为底物

Site PTM Type Enzyme
M1 Acetylation
S3 Phosphorylation
K8 Acetylation
K8 Methylation
K8 Ubiquitination
Y11 Phosphorylation
K23 Ubiquitination
Y24 Phosphorylation
Y25 Phosphorylation
K26 Ubiquitination
S35 Phosphorylation
K39 Acetylation
K39 Ubiquitination
K43 Acetylation
K43 Ubiquitination
K47 Ubiquitination
K96 Ubiquitination
K100 Ubiquitination
S108 Phosphorylation
Y113 Phosphorylation
K123 Ubiquitination
K136 Ubiquitination
Y203 Phosphorylation
Y204 Phosphorylation
K210 Ubiquitination

研究背景

功能:

Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.

亚基结构:

Monomer.

蛋白家族:

Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

研究领域

· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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