| 产品: | NUS1 抗体 |
| 货号: | DF13200 |
| 描述: | Rabbit polyclonal antibody to NUS1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 31 kDa; 33kD(Calculated). |
| 蛋白号: | Q96E22 |
| RRID: | AB_2846160 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13200, RRID:AB_2846160.
抗原和靶标
- Q96E22 NGBR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTGLYELVWRVLHALLCLHRTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPPAVGRNRRHHRHPRGGSCLAAAHHRMRWRADGRSLEKLPVHMGLVITEVEQEPSFSDIASLVVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEFANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDLVLKFGPVDSTLGFLPWHIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96E22 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S45 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| N144 | N-Glycosylation | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| N271 | N-Glycosylation | Uniprot |
研究背景
With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Note: Colocalizes with Nogo-B during VEGF and wound healing angiogenesis.
Forms an active dehydrodolichyl diphosphate synthase complex with DHDDS. Interacts with NPC2.
Belongs to the UPP synthase family.
研究领域
· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.
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