FAK Antibody - #AF6399

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产品: FAK 抗体
货号: AF6399
描述: Rabbit polyclonal antibody to FAK
应用: WB
文献验证: WB
反应: Human, Mouse
预测: Pig, Horse, Sheep, Dog, Chicken, Xenopus
蛋白号: Q05397
RRID: AB_2846187

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB(1:500-1:2000)
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
FAK Antibody detects endogenous levels of total FAK.
RRID:
AB_2846187
引用格式: Affinity Biosciences Cat# AF6399, RRID:AB_2846187.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FADK 1; FADK; FAK related non kinase polypeptide; FAK1; FAK1_HUMAN; Focal adhesion kinase 1; Focal adhesion Kinase; Focal adhesion kinase isoform FAK Del33; Focal adhesion kinase related nonkinase; FRNK; p125FAK; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; Protein tyrosine kinase 2; Protein-tyrosine kinase 2; Ptk2; PTK2 protein tyrosine kinase 2;

抗原和靶标

免疫原:

A synthesized peptide derived from human FAK, corresponding to a region within the internal amino acids.

基因/基因ID:
PTK2(5747)

研究领域

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Environmental Information Processing > Signal transduction > ErbB signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Cancers: Specific types > Small cell lung cancer.   (View pathway)

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

· Organismal Systems > Development > Axon guidance.   (View pathway)

· Organismal Systems > Immune system > Leukocyte transendothelial migration.   (View pathway)

文献引用

1). Abnormal N-glycosylated CPXM1 promotes gastric cancer metastasis through ITGB2 / FAK pathway. Research Square, 2021

Application: WB    Species: Human    Sample: GC tissues and normal gastric mucosa tissues

Figure 2. Abnormal glycosylation of CPXM1 protein in GC. A. IHC staining of GC tissues and normal gastric mucosa tissues. The left picture showed the expression of CPXM11 protein in GC tissues. The right picture showed the expression of CPXM1 protein in normal gastric mucosa tissues. B. The results of IHC staining in 96 gastric cancer tissues and 84 normal gastric mucosa tissues showed that the IHC scores of the two groups were not statistically significant (p >0.05). C. After WB detection of the previous 20 pairs of GC samples, it was found that CPXM1 in GC tissues was highly glycosylated (most of them were at 100kDa or 120kDa position, a small number were at 80kDa position), and most of CPXM1 in normal gastric mucosa tissues were at 80kDa or 100kDa position. D. By predicting the N-glycosylation site of CPXM1 through online database, we found that there may be four N-glycosylation sites on CPXM1, which are located in N57, N210, N318, N472.

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