产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13233, RRID:AB_2846252.
展开/折叠
hSK3; KCa2.3; Kcnn3; KCNN3_HUMAN; Potassium calcium activated channel subfamily N member 3; Potassium channel calcium activated intermediate/small conductance subfamily N alpha member 3; Potassium channel, calcium activated, intermediate/small conductance, subfamily N, member 3; Potassium intermediate/small conductance calcium activated channel subfamily N member 3; SK3; SKCa 3; SKCa3; Small conductance calcium-activated potassium channel protein 3;
抗原和靶标
- Q9UGI6 KCNN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UGI6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S159 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| T171 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| K550 | Ubiquitination | Uniprot | |
| K569 | Ubiquitination | Uniprot | |
| K615 | Sumoylation | Uniprot | |
| K620 | Ubiquitination | Uniprot | |
| K654 | Ubiquitination | Uniprot |
研究背景
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Membrane>Multi-pass membrane protein.
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
研究领域
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
限制条款
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