| 产品: | KCNK2 抗体 |
| 货号: | DF13242 |
| 描述: | Rabbit polyclonal antibody to KCNK2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 47kDa; 47kD(Calculated). |
| 蛋白号: | O95069 |
| RRID: | AB_2846261 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13242, RRID:AB_2846261.
展开/折叠
hTREK 1c; hTREK 1e; K2p2.1; K2P2.1 potassium channel; KCNK 2; Kcnk2; KCNK2_HUMAN; MGC126742; MGC126744; Outward rectifying potassium channel protein TREK 1; Outward rectifying potassium channel protein TREK-1; Outward rectifying potassium channel protein TREK1; Potassium channel subfamily K member 2; Potassium inwardly rectifying channel subfamily K member 2; Tandem pore domain potassium channel TREK 1; Tandem pore domain potassium channel TREK1; TPKC1; TREK 1; TREK 1 K(+) channel subunit; TREK; TREK-1 K(+) channel subunit; TREK1; TWIK related potassium channel 1; Two pore domain potassium channel TREK 1; Two pore domain potassium channel TREK-1; Two pore domain potassium channel TREK1; Two pore potassium channel 1; Two pore potassium channel TPKC1;
抗原和靶标
Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
- O95069 KCNK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95069 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S36 | Phosphorylation | Uniprot | |
| Y72 | Phosphorylation | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| S385 | Phosphorylation | Uniprot |
研究背景
Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).
Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2.
Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.
Cell membrane>Multi-pass membrane protein.
Cell membrane>Multi-pass membrane protein.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
Homodimer; disulfide-linked (Ref.13). Heterodimer with KCNK1; disulfide-linked (By similarity). Interacts with BVES; the interaction enhances KCNK2 surface expression and is inhibited by cAMP.
The C-terminal region of isoform 4 mediates its intracellular retention.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
研究领域
· Organismal Systems > Digestive system > Gastric acid secretion.
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