| 产品: | Cyclophilin 40 抗体 |
| 货号: | DF13246 |
| 描述: | Rabbit polyclonal antibody to Cyclophilin 40 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 40kDa; 41kD(Calculated). |
| 蛋白号: | Q08752 |
| RRID: | AB_2846265 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13246, RRID:AB_2846265.
展开/折叠
40 kDa peptidyl prolyl cis trans isomerase; 40 kDa peptidyl prolyl cis trans isomerase D; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin D; Cyclophilin related protein; Cyclophilin-40; Cyclophilin-related protein; Cyclophilin40; CyclophilinD; CYP 40; CYP-40; CYP40; CYPD; MGC33096; Peptidyl Prolyl Isomerase D; Peptidyl-prolyl cis-trans isomerase D; Peptidylprolyl isomerase D; PPIase; PPIase D; Ppid; PPID_HUMAN; Rotamase; Rotamase D;
抗原和靶标
- Q08752 PPID_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q08752 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S5 | Phosphorylation | Uniprot | |
| K9 | Ubiquitination | Uniprot | |
| K43 | Sumoylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K102 | Sumoylation | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K168 | Acetylation | Uniprot | |
| K168 | Sumoylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| T223 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K235 | Methylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| Y246 | Phosphorylation | Uniprot | |
| R251 | Methylation | Uniprot | |
| Y252 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| C275 | S-Nitrosylation | Uniprot | |
| C282 | S-Nitrosylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| Y323 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K341 | Sumoylation | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| Y365 | Phosphorylation | Uniprot | |
| K367 | Ubiquitination | Uniprot |
研究背景
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines.
(Microbial infection) May be involved in hepatitis C virus (HCV) replication and release.
Cytoplasm. Nucleus>Nucleolus. Nucleus>Nucleoplasm.
Widely expressed.
Identified in ESR1 or NR3C1/GCR steroid receptor-chaperone complexes. Found in HSP90 chaperone complexes with kinase clients LCK or EIF2AK1. Two monomers associate with one HSP90 homodimer. Interacts with HSP90AA1. Interacts with HSP90AB1; PPID and FKBP4 compete for binding to HSP90AB1 and the interaction is mutually exclusive with the PPID:HSPA8 interaction. Interacts with HSPA8; PPID and STIP1 but not FKBP4 compete for binding to HSPA8 and the interaction is mutually exclusive with the PPID:HSP90AB1 interaction. Interacts with S100A1 and S100A2; the interactions dissociate the PPID:HSP90AA1 interaction. Interacts with S100A6. Interacts with MYB, ILF2, XRCC6, RACK1 and RPS3. Interacts with cytoplasmic dynein 1 intermediate chain (DYNC1I1 or DYNC1I2).
Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
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