(1)
(5)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13260, RRID:AB_2846279.
展开/折叠
3-1; 6-alpha-mannosidase; Alpha mannosidase 2; alpha Mannosidase II; Alpha-mannosidase 2; AMAN II; Golgi alpha mannosidase II; Golgi alpha-mannosidase II; Golgi integral membrane protein 7; GOLIM7; MA2A1_HUMAN; MAN II; Man2a1; MANA 2; MANA2; MANII; Mann II; Mannosidase alpha class 2A member 1; Mannosidase Two; Mannosidase, alpha type II; Mannosidase, alpha, II; Mannosyl oligosaccharide 1 3 1 6 alpha mannosidase; Mannosyl oligosaccharide 1,3 1,6 alpha mannosidase; Mannosyl-oligosaccharide 1;
抗原和靶标
- Q16706 MA2A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q16706 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y33 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| N78 | N-Glycosylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| S105 | O-Glycosylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| Y194 | Phosphorylation | Uniprot | |
| Y218 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| K373 | Ubiquitination | Uniprot | |
| Y407 | Phosphorylation | Uniprot | |
| Y442 | Phosphorylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| T509 | Phosphorylation | Uniprot | |
| Y514 | Phosphorylation | Uniprot | |
| Y532 | Phosphorylation | Uniprot | |
| Y533 | Phosphorylation | Uniprot | |
| K716 | Ubiquitination | Uniprot | |
| S723 | Phosphorylation | Uniprot | |
| Y733 | Phosphorylation | Uniprot | |
| K737 | Ubiquitination | Uniprot | |
| K739 | Ubiquitination | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| T747 | Phosphorylation | Uniprot | |
| K801 | Ubiquitination | Uniprot | |
| Y852 | Phosphorylation | Uniprot | |
| S865 | Phosphorylation | Uniprot | |
| K887 | Ubiquitination | Uniprot | |
| S998 | Phosphorylation | Uniprot | |
| N1125 | N-Glycosylation | Uniprot |
研究背景
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Glycosylated.
Golgi apparatus membrane>Single-pass type II membrane protein.
Homodimer; disulfide-linked.
Belongs to the glycosyl hydrolase 38 family.
研究领域
· Metabolism > Glycan biosynthesis and metabolism > N-Glycan biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
文献引用
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