产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13272, RRID:AB_2846291.
展开/折叠
;Syntrophin like; 59 kDa dystrophin associated protein A1 basic component 2; 59 kDa dystrophin-associated protein A1 basic component 2; Basic beta 2 syntrophin; Beta 2 syntrophin; Beta-2-syntrophin; D16S2531E; Dystrophin associated protein A1 59kD basic component 2; EST25263; SNT2B2; SNT3; Sntb2; SNTB2_HUMAN; SNTL; Syntrophin 3; Syntrophin beta 2 (dystrophin associated protein A1 59kDa basic component 2); Syntrophin-3; Syntrophin-like;
抗原和靶标
Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.
- Q13425 SNTB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13425 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T7 | Phosphorylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| K184 | Methylation | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K188 | Ubiquitination | Uniprot | |
| T201 | Phosphorylation | Uniprot | |
| K205 | Acetylation | Uniprot | |
| K206 | Acetylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S222 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K235 | Acetylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| K489 | Ubiquitination | Uniprot |
研究背景
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Phosphorylated. Partially dephosphorylated upon insulin stimulation.
Membrane. Cytoplasmic vesicle>Secretory vesicle membrane>Peripheral membrane protein. Cell junction. Cytoplasm>Cytoskeleton.
Note: Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules.
Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.
Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN.
The PH 1 domain mediates the oligomerization in a calcium dependent manner.
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).
The SU domain binds calmodulin in a calcium-dependent manner.
Belongs to the syntrophin family.
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