| 产品: | TEAD4 抗体 |
| 货号: | DF13283 |
| 描述: | Rabbit polyclonal antibody to TEAD4 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Horse, Sheep, Rabbit, Chicken |
| 分子量: | 48kDa, 60 kDa; 48kD(Calculated). |
| 蛋白号: | Q15561 |
| RRID: | AB_2846302 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13283, RRID:AB_2846302.
展开/折叠
EFTR 2; EFTR2; hRTEF 1B; hRTEF1B; MGC9014; OTTHUMP00000238119; OTTHUMP00000238122; OTTHUMP00000238124; Related to TEF 1; Related to TEF1; Related transcription enhancer factor 1B; RTEF1; TCF13L1; TEA domain family member 4; TEAD 4; TEAD-4; TEAD4; TEAD4_HUMAN; TEF 3; TEF3; TEFR 1; TEFR1; Transcription factor 13 (SV40 transcriptional enhancer factor) like 1; Transcription factor 13 like 1; Transcription factor 13-like 1; Transcription factor RTEF 1; Transcription factor RTEF-1; Transcription factor RTEF1; Transcriptional enhancer factor 1 related; Transcriptional enhancer factor 3; Transcriptional enhancer factor TEF 3; Transcriptional enhancer factor TEF-3; Transcriptional enhancer factor TEF3;
抗原和靶标
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
- Q15561 TEAD4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15561 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K65 | Ubiquitination | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| K91 | Methylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K178 | Sumoylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| Y271 | Phosphorylation | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K278 | Acetylation | Uniprot | |
| K282 | Acetylation | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| Y352 | Phosphorylation | Uniprot | |
| Y357 | Phosphorylation | Uniprot | |
| S420 | Phosphorylation | Uniprot |
研究背景
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Nucleus.
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Interacts with YAP1 and WWTR1/TAZ.
研究领域
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway - multiple species. (View pathway)
限制条款
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