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| 产品: | KDM6A / UTX 抗体 |
| 货号: | DF13286 |
| 描述: | Rabbit polyclonal antibody to KDM6A / UTX |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 154kDa; 154kD(Calculated). |
| 蛋白号: | O15550 |
| RRID: | AB_2846305 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13286, RRID:AB_2846305.
展开/折叠
bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX); bA386N14.2; bA386N14.2 ubiquitously transcribed X chromosome tetratricopeptide repeat protein UTX; DKFZp686A03225; Histone demethylase UTX; KABUK2; Kdm6a; KDM6A_HUMAN; Lysine (K) specific demethylase 6A; Lysine K specific demethylase 6A; Lysine specific demethylase 6A ubiquitously transcribed tetratricopeptide repeat gene X chromosome; Lysine-specific demethylase 6A; MGC141941; Ubiquitously transcribed tetratricopeptide repeat X chromosome; Ubiquitously transcribed tetratricopeptide repeat protein X linked; Ubiquitously transcribed TPR gene on the X chromosome; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; UTX;
抗原和靶标
- O15550 KDM6A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKSCGVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEEREALGGLDSRLFGFVRFHEDGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQVKATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSKSCSNTSALAARIKYLQAQLCNLPQGSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQQNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTGVAQVRSTGIPNGPTADSSLPTNSVSGQQPQLALTRVPSVSQPGVRPACPGQPLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITGSGSNGNVPYLQRNALTLPHNRTNLTSSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNILTVPETSRHTGETPNSTASVEGLPNHVHQMTADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGTGTCDKVNNIHPAVHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPMKTDLLLVNHKPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPPLPSASS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O15550 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K225 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| T387 | Phosphorylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| T535 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S552 | Phosphorylation | Uniprot | |
| R621 | Methylation | Uniprot | |
| K719 | Sumoylation | Uniprot | |
| S761 | Phosphorylation | Uniprot | |
| S769 | Phosphorylation | Uniprot | |
| K799 | Acetylation | Uniprot | |
| T811 | Phosphorylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| S818 | Phosphorylation | Uniprot | |
| T827 | Phosphorylation | Uniprot | |
| S829 | Phosphorylation | Uniprot | |
| S926 | Phosphorylation | Uniprot | |
| Y928 | Phosphorylation | Uniprot | |
| K1018 | Ubiquitination | Uniprot | |
| K1053 | Ubiquitination | Uniprot | |
| S1061 | Phosphorylation | Uniprot | |
| S1091 | Phosphorylation | Uniprot | |
| K1097 | Ubiquitination | Uniprot | |
| T1131 | Phosphorylation | Uniprot | |
| S1284 | Phosphorylation | Uniprot | |
| K1287 | Ubiquitination | Uniprot | |
| K1301 | Ubiquitination | Uniprot |
研究背景
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).
Nucleus.
Interacts with TLE1 (By similarity). Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A (or KDM6B), PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with SUPT6H. Interacts with SMARCA4 (By similarity).
Belongs to the UTX family.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
文献引用
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