Mineralocorticoid Receptor Antibody - #DF13302
| 产品: | Mineralocorticoid Receptor 抗体 |
| 货号: | DF13302 |
| 描述: | Rabbit polyclonal antibody to Mineralocorticoid Receptor |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Bovine, Horse, Rabbit, Dog |
| 分子量: | 107kDa; 107kD(Calculated). |
| 蛋白号: | P08235 |
| RRID: | AB_2846321 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13302, RRID:AB_2846321.
展开/折叠
Aldosterone receptor; MCR; MCR_HUMAN; MGC133092; Mineralocorticoid receptor; MLR; MR; NR3 C2; NR3C2; NR3C2 protein; Nuclear receptor subfamily 3 group C member 2;
抗原和靶标
Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
- P08235 MCR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAVVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P08235 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| Y6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| K89 | Sumoylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| T159 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| S227 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| S248 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| K399 | Sumoylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| K428 | Sumoylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| K464 | Acetylation | Uniprot | |
| K494 | Sumoylation | Uniprot | |
| T532 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| K680 | Ubiquitination | Uniprot | |
| S703 | Phosphorylation | Uniprot | |
| T735 | Phosphorylation | Uniprot | |
| S737 | Phosphorylation | Uniprot | |
| T761 | Phosphorylation | Uniprot | |
| S843 | Phosphorylation | Uniprot | |
| K953 | Sumoylation | Uniprot | |
| K970 | Ubiquitination | Uniprot | |
| K977 | Ubiquitination | Uniprot |
研究背景
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Phosphorylated.
Cytoplasm. Nucleus. Endoplasmic reticulum membrane>Peripheral membrane protein.
Note: Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Belongs to the nuclear hormone receptor family. NR3 subfamily.
研究领域
· Organismal Systems > Excretory system > Aldosterone-regulated sodium reabsorption.
限制条款
产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。
产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。
Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。产品仅供科学研究使用。不用于诊断和治疗。
产品未经授权不得转售。
Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.