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| 产品: | FKBP51 抗体 |
| 货号: | DF13305 |
| 描述: | Rabbit polyclonal antibody to FKBP51 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 51kDa; 51kD(Calculated). |
| 蛋白号: | Q13451 |
| RRID: | AB_2846324 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13305, RRID:AB_2846324.
展开/折叠
51 kDa FK506 binding protein 5; 51 kDa FK506 binding protein; 51 kDa FK506-binding protein; 51 kDa FKBP; 54 kDa progesterone receptor associated immunophilin; 54 kDa progesterone receptor-associated immunophilin; AIG 6; AIG6; Androgen regulated protein 6; Androgen-regulated protein 6; FF1 antigen; FK506 binding protein 5; FK506-binding protein 5; FKBP 5; FKBP 51; FKBP 54; FKBP-5; FKBP-51; FKBP5; FKBP5_HUMAN; FKBP54; HSP90 binding immunophilin; HSP90-binding immunophilin; MGC111006; OTTHUMP00000016268; P54; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP5; Peptidylprolyl cis trans isomerase; PPIase; PPIase FKBP5; Ptg 10; Ptg10; Rotamase; T cell FK506 binding protein;
抗原和靶标
- Q13451 FKBP5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRMFDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQDAKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13451 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| T15 | Phosphorylation | Uniprot | |
| K28 | Acetylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| K155 | Acetylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| Y243 | Phosphorylation | Uniprot | |
| K248 | Acetylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| R357 | Methylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| Y409 | Phosphorylation | Uniprot | |
| K414 | Acetylation | Uniprot | |
| K415 | Acetylation | Uniprot | |
| K422 | Sumoylation | Uniprot | |
| K422 | Ubiquitination | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| K441 | Acetylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| T443 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot |
研究背景
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1.
Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation.
Cytoplasm. Nucleus.
Widely expressed, enriched in testis compared to other tissues.
Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place (By similarity). Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Interacts with NR3C1 (By similarity). Interacts with Akt/AKT1 and PHLPP1; enhancing dephosphorylation and subsequent activation of Akt/AKT1.
研究领域
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
文献引用
Application: WB Species: Mouse Sample:
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