(2)
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| 产品: | TRP1 抗体 |
| 货号: | DF13325 |
| 描述: | Rabbit polyclonal antibody to TRP1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 60kDa; 61kD(Calculated). |
| 蛋白号: | P17643 |
| RRID: | AB_2846344 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13325, RRID:AB_2846344.
展开/折叠
5; 5,6 dihydroxyindole 2 carboxylic acid oxidase; 6-dihydroxyindole-2-carboxylic acid oxidase; b-PROTEIN; CAS2; Catalase B; CATB; DHICA oxidase; Glycoprotein 75; GP75; Melanoma antigen gp75; OCA3; TRP; TRP-1; TRP1; Tyrosinase related protein 1; Tyrosinase-related protein 1; TYRP; TYRP1; TYRP1_HUMAN; TYRRP;
抗原和靶标
- P17643 TYRP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSAPKLLSLGCIFFPLLLFQQARAQFPRQCATVEALRSGMCCPDLSPVSGPGTDRCGSSSGRGRCEAVTADSRPHSPQYPHDGRDDREVWPLRFFNRTCHCNGNFSGHNCGTCRPGWRGAACDQRVLIVRRNLLDLSKEEKNHFVRALDMAKRTTHPLFVIATRRSEEILGPDGNTPQFENISIYNYFVWTHYYSVKKTFLGVGQESFGEVDFSHEGPAFLTWHRYHLLRLEKDMQEMLQEPSFSLPYWNFATGKNVCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCDSLEDYDTLGTLCNSTEDGPIRRNPAGNVARPMVQRLPEPQDVAQCLEVGLFDTPPFYSNSTNSFRNTVEGYSDPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYTYEIQWPSREFSVPEIIAIAVVGALLLVALIFGTASYLIRARRSMDEANQPLLTDQYQCYAEEYEKLQNPNQSVV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P17643 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| N96 | N-Glycosylation | Uniprot | |
| N104 | N-Glycosylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| N181 | N-Glycosylation | Uniprot | |
| S207 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| S270 | Phosphorylation | Uniprot | |
| N304 | N-Glycosylation | Uniprot | |
| N350 | N-Glycosylation | Uniprot | |
| N385 | N-Glycosylation | Uniprot |
研究背景
Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
Glycosylated.
Melanosome membrane>Single-pass type I membrane protein. Melanosome.
Note: Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Pigment cells.
Monomer.
Belongs to the tyrosinase family.
研究领域
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Melanogenesis.
文献引用
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