| 产品: | AKR1B10 抗体 |
| 货号: | DF13405 |
| 描述: | Rabbit polyclonal antibody to AKR1B10 |
| 应用: | WB IHC |
| 反应: | Human |
| 分子量: | 36kDa; 36kD(Calculated). |
| 蛋白号: | O60218 |
| RRID: | AB_2846424 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13405, RRID:AB_2846424.
展开/折叠
AK1BA_HUMAN; AKR1B10; AKR1B11; AKR1B12; Aldo keto reductase family 1 member B10; aldo keto reductase family 1 member B11; Aldo-keto reductase family 1 member B10 (aldose reductase); Aldo-keto reductase family 1 member B10; Aldo-keto reductase family 1 member B11 (aldose reductase-like); aldose reductase like 1; Aldose reductase like; aldose reductase like peptide; Aldose reductase related protein; Aldose reductase-like; Aldose reductase-related protein; ALDRLn; ARL 1; ARL-1; ARL1; ARL1 Human small intestine reductase; ARP; hARP; HIS; HSI; SI reductase; Small intestine reductase;
抗原和靶标
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
- O60218 AK1BA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
翻译修饰 - O60218 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| K27 | Acetylation | Uniprot | |
| Y40 | Phosphorylation | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| Y49 | Phosphorylation | Uniprot | |
| K69 | Acetylation | Uniprot | |
| R70 | Methylation | Uniprot | |
| K95 | Acetylation | Uniprot | |
| K125 | Acetylation | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K179 | Acetylation | Uniprot | |
| Y190 | Phosphorylation | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| K263 | Acetylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T288 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| Y310 | Phosphorylation | Uniprot | |
| Y316 | Phosphorylation | Uniprot |
研究背景
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose.
Lysosome. Secreted.
Note: Secreted through a lysosome-mediated non-classical pathway.
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Belongs to the aldo/keto reductase family.
研究领域
· Metabolism > Carbohydrate metabolism > Pentose and glucuronate interconversions.
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Lipid metabolism > Glycerolipid metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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