KCNK5 Antibody - #DF13412
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13412, RRID:AB_2846431.
展开/折叠
Acid sensitive potassium channel protein TASK 2; Acid-sensitive potassium channel protein TASK-2; FLJ11035; K2p5.1; KCNK 5; KCNK5; KCNK5_HUMAN; Potassium channel subfamily K member 1; Potassium channel subfamily K member 5; TASK 2; TASK2; TWIK related acid sensitive K(+) channel 2; TWIK related acid sensitive K+ channel 2; TWIK-related acid-sensitive K(+) channel 2;
抗原和靶标
Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.
- O95279 KCNK5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95279 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K36 | Ubiquitination | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| T300 | Phosphorylation | Uniprot | |
| Y301 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| Y347 | Phosphorylation | Uniprot | |
| T354 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| Y410 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot |
研究背景
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.
Membrane>Multi-pass membrane protein.
Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.
Homodimer; disulfide-linked.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
研究领域
· Organismal Systems > Sensory system > Taste transduction.
· Organismal Systems > Digestive system > Protein digestion and absorption.
限制条款
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