| 产品: | TEM8 抗体 |
| 货号: | DF13424 |
| 描述: | Rabbit polyclonal antibody to TEM8 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 62kDa; 63kD(Calculated). |
| 蛋白号: | Q9H6X2 |
| RRID: | AB_2846443 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13424, RRID:AB_2846443.
展开/折叠
Anthrax toxin receptor 1; ANTR1_HUMAN; Antxr1; ATR; Tumor endothelial marker 8;
抗原和靶标
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
- Q9H6X2 ANTR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9H6X2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| Y119 | Phosphorylation | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| Y133 | Phosphorylation | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| N184 | N-Glycosylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| T377 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| Y382 | Phosphorylation | Uniprot | |
| Y383 | Phosphorylation | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| Y425 | Phosphorylation | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K451 | Ubiquitination | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| K488 | Ubiquitination | Uniprot | |
| Y501 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S563 | Phosphorylation | Uniprot |
研究背景
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
Cell membrane>Single-pass type I membrane protein. Cell projection>Lamellipodium membrane>Single-pass type I membrane protein. Cell projection>Filopodium membrane>Single-pass type I membrane protein.
Note: At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.
Binding to PA occurs through the VWA domain.
Belongs to the ATR family.
研究领域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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