| 产品: | TBL1 抗体 |
| 货号: | DF13425 |
| 描述: | Rabbit polyclonal antibody to TBL1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 62kDa; 62kD(Calculated). |
| 蛋白号: | O60907 |
| RRID: | AB_2846444 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13425, RRID:AB_2846444.
展开/折叠
EBI; F box like/WD repeat protein TBL1X; F-box-like/WD repeat-containing protein TBL1X; SMAP 55; SMAP55; TBL 1; TBL 1X; TBL1; TBL1X; TBL1X_HUMAN; Transducin (beta) like 1; Transducin (beta) like 1 X linked; Transducin (beta) like 1X linked; Transducin beta like 1 X linked; Transducin beta like 1X; Transducin beta like 1X protein; Transducin beta like protein 1, X linked; Transducin beta-like protein 1X; Transducin-beta-like protein 1; X-linked;
抗原和靶标
- O60907 TBL1X_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
翻译修饰 - O60907 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T43 | Phosphorylation | Uniprot | |
| T55 | Phosphorylation | Uniprot | |
| S160 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| T173 | Phosphorylation | Uniprot | |
| T176 | Phosphorylation | Uniprot | |
| T177 | Phosphorylation | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| T226 | Phosphorylation | Uniprot | |
| K329 | Ubiquitination | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| T383 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S474 | Phosphorylation | Uniprot | |
| Y509 | Phosphorylation | Uniprot | |
| K518 | Ubiquitination | Uniprot | |
| K527 | Methylation | Uniprot | |
| K560 | Sumoylation | Uniprot |
研究背景
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
Nucleus.
Note: Colocalized with MECP2 to the heterochromatin foci.
Ubiquitous.
Homotetramer; dimer of dimers. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with GPS2 (when sumoylated); leading to protect GPS2 against degradation by the proteasome. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4. Interacts with MECP2; recruits TBL1X to the heterochromatin foci (By similarity).
The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
Belongs to the WD repeat EBI family.
研究领域
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
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