产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13426, RRID:AB_2846445.
展开/折叠
C21; DC42; F box like/WD repeat containing protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; IRA1; Nuclear receptor corepressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1 related protein 1; TBL1-related protein 1; TBL1R_HUMAN; TBL1XR1; TBLR1; Transducin (beta) like 1 X linked receptor 1; Transducin beta like 1X related protein 1; Transducin beta-like 1X-related protein 1;
抗原和靶标
Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.
- Q9BZK7 TBL1R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQAAAAAAAAAAASQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9BZK7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K102 | Acetylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Q05655 (PRKCD) | Uniprot |
| S199 | Phosphorylation | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| K254 | Acetylation | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| K277 | Acetylation | Uniprot | |
| K277 | Sumoylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K392 | Ubiquitination | Uniprot | |
| R431 | Methylation | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| K464 | Methylation | Uniprot | |
| K497 | Sumoylation | Uniprot |
研究背景
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
Nucleus.
Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.
Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4. Interacts with MECP2; bridges interaction between MECP2 and NCOR1 (By similarity).
The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.
Belongs to the WD repeat EBI family.
研究领域
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
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