产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13437, RRID:AB_2846456.
展开/折叠
3D3; 3D3/LYRIC; AEG 1; AEG-1; AEG1; Astrocyte elevated gene 1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC/3D3; LYRIC_HUMAN; Lysine rich CEACAM1 associated protein; Lysine rich CEACAM1 co isolated protein; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; MTDH; Protein LYRIC;
抗原和靶标
Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
- Q86UE4 LYRIC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q86UE4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S84 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| T143 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K170 | Acetylation | Uniprot | |
| K174 | Acetylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| S219 | Phosphorylation | Uniprot | |
| K248 | Ubiquitination | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| K261 | Methylation | Uniprot | |
| K264 | Methylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| T268 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| T280 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| K314 | Acetylation | Uniprot | |
| K314 | Methylation | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| R338 | Methylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| T361 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| Y364 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| S411 | Phosphorylation | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| S426 | Phosphorylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| K441 | Acetylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| T458 | Phosphorylation | Uniprot | |
| T462 | Phosphorylation | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| K491 | Methylation | Uniprot | |
| K491 | Ubiquitination | Uniprot | |
| T492 | Phosphorylation | Uniprot | |
| S494 | Phosphorylation | Uniprot | |
| T495 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| S506 | Phosphorylation | Uniprot | |
| K510 | Ubiquitination | Uniprot | |
| T511 | Phosphorylation | Uniprot | |
| S521 | Phosphorylation | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| S534 | Phosphorylation | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| T550 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| T560 | Phosphorylation | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| T564 | Phosphorylation | Uniprot | |
| S565 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| K570 | Ubiquitination | Uniprot | |
| T582 | Phosphorylation | Uniprot |
研究背景
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Endoplasmic reticulum membrane>Single-pass membrane protein. Nucleus membrane>Single-pass membrane protein. Cell junction>Tight junction. Nucleus>Nucleolus. Cytoplasm>Perinuclear region.
Note: In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.
Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
Interacts with BCCIP, CREBBP/CBP and RELA/p65.
限制条款
产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。
产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。
Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。产品仅供科学研究使用。不用于诊断和治疗。
产品未经授权不得转售。
Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.