| 产品: | PGAM2 抗体 |
| 货号: | DF13447 |
| 描述: | Rabbit polyclonal antibody to PGAM2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 28kDa; 29kD(Calculated). |
| 蛋白号: | P15259 |
| RRID: | AB_2846466 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13447, RRID:AB_2846466.
展开/折叠
BPG dependent PGAM 2; BPG-dependent PGAM 2; GSD10; MGC88743; Muscle specific phosphoglycerate mutase; Muscle-specific phosphoglycerate mutase; OTTHUMP00000207787; PGAM 2; PGAM M; PGAM-M; Pgam2; PGAM2_HUMAN; PGAMM; phosphoglycerate mutase 2 (muscle); Phosphoglycerate mutase 2; Phosphoglycerate mutase isozyme M;
抗原和靶标
- P15259 PGAM2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P15259 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| K33 | Acetylation | Uniprot | |
| K39 | Acetylation | Uniprot | |
| R90 | Methylation | Uniprot | |
| Y92 | Phosphorylation | Uniprot | |
| T96 | Phosphorylation | Uniprot | |
| K100 | Acetylation | Uniprot | |
| K100 | Sumoylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| Y133 | Phosphorylation | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K241 | Methylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot |
研究背景
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Expressed in the heart and muscle. Not found in the liver and brain.
Homodimer. Interacts with ENO1.
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
研究领域
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Amino acid metabolism > Glycine, serine and threonine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
限制条款
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