产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13468, RRID:AB_2846487.
展开/折叠
1110017A08Rik; dJ496H19.1; KCP 1; KCP-1; KCP1; Keratinocyte associated protein 1; Keratinocyte-associated protein 1; Keratinocytes associated protein 1; KRTCAP 1; KRTCAP1; p53 apoptosis effector related to PMP 22; p53 apoptosis effector related to PMP-22; p53 apoptosis effector related to PMP22; P53 induced protein PIGPC1; P53-induced protein PIGPC1; Perp; PERP TP53 apoptosis effector; PERP_HUMAN; PIGPC 1; PIGPC1; RP3 496H19.1; THW; TP53 apoptosis effector; Transmembrane protein THW;
抗原和靶标
Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.
- Q96FX8 PERP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSDHGQTSSLWWKCSQEGGGSGSYEEGCQSLMEYAWGRAAAAMLFCGFIILVICFILSFFALCGPQMLVFLRVIGGLLALAAVFQIISLVIYPVKYTQTFTLHANPAVTYIYNWAYGFGWAATIILIGCAFFFCCLPNYEDDLLGNAKPRYFYTSA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96FX8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot |
研究背景
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).
Cell junction>Desmosome. Cell membrane>Multi-pass membrane protein.
Note: Associated with desmosomes.
Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.
Belongs to the TMEM47 family.
研究领域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
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