产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13480, RRID:AB_2846499.
展开/折叠
2P domain potassium channel TREK2; K2p10.1; KCNK10; KCNKA_HUMAN; Outward rectifying potassium channel protein TREK 2; Outward rectifying potassium channel protein TREK-2; Potassium channel subfamily K member 10; Potassium channel TREK 2; TREK 2; TREK 2 K; TREK 2 K(+) channel subunit; TREK-2 K(+) channel subunit; TREK2; TWIK related K+ channel 2;
抗原和靶标
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
- P57789 KCNKA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P57789 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y82 | Phosphorylation | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| Y479 | Phosphorylation | Uniprot |
研究背景
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
Membrane>Multi-pass membrane protein.
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
研究领域
· Organismal Systems > Digestive system > Gastric acid secretion.
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