| 产品: | PEN2 抗体 |
| 货号: | DF13538 |
| 描述: | Rabbit polyclonal antibody to PEN2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 12kDa; 12kD(Calculated). |
| 蛋白号: | Q9NZ42 |
| RRID: | AB_2846557 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13538, RRID:AB_2846557.
展开/折叠
Gamma secretase subunit PEN 2; Gamma Secretase Subunit PEN2; Gamma-secretase subunit PEN-2; Hematopoietic stem/progenitor cells protein MDS033; MDS033; MSTP064; PEN 2; PEN2_HUMAN; Presenilin Enhancer 2; Presenilin enhancer 2 homolog; Presenilin enhancer protein 2; PSEN2; psenen;
抗原和靶标
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
- Q9NZ42 PEN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NZ42 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Ubiquitination | Uniprot |
研究背景
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
Endoplasmic reticulum membrane>Multi-pass membrane protein. Golgi apparatus>Golgi stack membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein. Membrane>Multi-pass membrane protein.
Note: Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN.
Belongs to the PEN-2 family.
研究领域
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
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