HDAC3 Antibody - #AF6016

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产品: HDAC3 抗体
货号: AF6016
描述: Rabbit polyclonal antibody to HDAC3
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: O15379
RRID: AB_2834950

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
HDAC3 Antibody detects endogenous levels of total HDAC3.
RRID:
AB_2834950
引用格式: Affinity Biosciences Cat# AF6016, RRID:AB_2834950.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

HD3; HDAC 3; HDAC3; HDAC3_HUMAN; Histone deacetylase 3; RPD3 2; RPD3; RPD3-2; SMAP45;

抗原和靶标

免疫原:

A synthesized peptide derived from human HDAC3, corresponding to a region within C-terminal amino acids.

基因/基因ID:
HDAC3(8841)
描述:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.

研究领域

· Human Diseases > Substance dependence > Alcoholism.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

文献引用

1). A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development. Leukemia, 2023 (PubMed: 37157016) [IF=12.8]
2). β-1,3-glucans from Euglena Gracilis protects against ulcerative colitis via modulating the gut barrier, T-cell immunity and gut microbiota. International journal of biological macromolecules, 2025 (PubMed: 39984099) [IF=7.7]
3). Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice. ACTA PHARMACOLOGICA SINICA, 2020 (PubMed: 31937933) [IF=6.9]

Application: WB    Species: Mouse    Sample: Colonic tissue

Fig. 6 HDAC3 protein expression in mouse colonic samples. Total protein was extracted from mouse colon specimens at different time points (a: 0 weeks, b: 8 weeks), and the levels of HDAC3 were analyzed by using Western blot. The signal intensity was quantified by using densitometry and is expressed relative to β-actin expression (c). Values are the mean ± S.D. *P < 0.05 compared with db/m + PBS mice. #P < 0.05 compared with db/db + PBS mice.
4). Chitotriosidase attenuates brain inflammation via HDAC3/NF-κB pathway in D-galactose and aluminum-induced rat model with cognitive impairments. NEUROSCIENCE RESEARCH, 2021 (PubMed: 34111442) [IF=2.4]

Application: WB    Species: rat    Sample: brain

Fig. 2. |Levels of HDAC3 in four experimental groups. (a) The mRNA levels of HDAC3 in the brain tissue were detected via qRT-PCR. (b) The protein levels of HDAC3 in the brain tissue of rats were determined by western blotting. GAPDH was used as a loading control. * p < 0.05.

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