产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13591, RRID:AB_2846610.
展开/折叠
CD_antigen=CD158d; CD158 antigen like family member D; CD158 antigen-like family member D; CD158d; G9P; KI2L4_HUMAN; Killer cell immunoglobulin like receptor 2DL4; Killer cell immunoglobulin like receptor, two domains, long cytoplasmic tail, 4; Killer cell immunoglobulin-like receptor 2DL4; Killer cell inhibitory receptor 103AS; Killer Ig receptor; KIR 103AS; KIR-103AS; KIR103; KIR103AS; KIR2DL4; MHC class I NK cell receptor KIR103AS; Natural killer cell inhibitory receptor; NK cell receptor; NK cell receptor; natural killer cell inhibitory receptor; OTTHUMP00000068612; OTTHUMP00000068614; OTTHUMP00000068615;
抗原和靶标
Expressed in decidual NK cells and innate lymphoid cell type I (ILC1) (PubMed:29262349). Expressed in a subset of peripheral NK cells (PubMed:19304799).
- Q99706 KI2L4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHAVIRYSVAIILFTILPFFLLHRWCSKKKDAAVMNQEPAGHRTVNREDSDEQDPQEVTYAQLDHCIFTQRKITGPSQRSKRPSTDTSVCIELPNAEPRALSPAHEHHSQALMGSSRETTALSQTQLASSNVPAAGI
翻译修饰 - Q99706 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y74 | Phosphorylation | Uniprot | |
| T120 | Phosphorylation | Uniprot | |
| Y123 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S356 | Phosphorylation | Uniprot |
研究背景
Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response.
Cell membrane>Single-pass type I membrane protein. Early endosome membrane.
Expressed in decidual NK cells and innate lymphoid cell type I (ILC1). Expressed in a subset of peripheral NK cells.
Interacts with peptide-bound HLA-G-B2M heterotrimeric complex. Interacts with ARRB2.
Belongs to the immunoglobulin superfamily.
研究领域
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Organismal Systems > Immune system > Antigen processing and presentation. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
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